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Long term observation of using fibrin glue combined with pingyangmycin for embol

2013-07-26 15:21:02 Source: Author:YANG Qing-tian1, YANG Yao-wu1, SUN Mo-yi1,LEI De-lin1, LIU Gui-cai1, WANG Wei-qi1, CHEN Cheng1, GUO Jun2, SHI Li-qiang3, LIU Bao-lin1. Hits:0
[Abstract] PURPOSE: To evaluate the outcome of fibrin glue (FG) combined with pingyangmycin for the treatment of cervicofacial venous malformation (VM). METHODS: The data of 78 cases with VM from January 2005 to January 2012 was reviewed. Of the 78 cases, 63 underwent embolization and sclerotherapy of FG combined with pingyangmycin, and subsequent injection of pingyangmycin only; 15 underwent injection of ethanol, radiofrequency ablation, or surgical resection besides embolization and sclerotherapy of FG combined with pingyangmycin. The vital signs and symptoms after treatments were observed. Chest X-ray film was taken for evaluation of pulmonary status. The therapeutic effect was evaluated by clinical examination, ultrasonography with Doppler, or magnetic resonance imaging (MRI). The follow-up time was from 6 months to 7 years. RESULTS: Of the 78 patients, 41 were male and 37 were female, ranging in age from 10 to 66 years (mean, 26 years). Sixty seven of 78 lesions (85.9%) showed greater than 90% reduction, whereas another 11 (14.1%) exhibited greater than 50% reduction. Six patients had fever. There was no allergic reaction, pulmonary embolization or other complications after treatment. CONCLUSION: Embolization and sclerotherapy of FG combined with pingyangmycin for cervicofacial VMs was safe and effective. The complications are acceptable. It was a promising therapeutic method for larger and rapid draining VMs.
[Key words]  Venous malformation;Pingyangmycin;Fibrin glue;Sclerotherapy; Embolization

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