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Genetics and Genomics of Vascular Disease Workshop

2009-08-14 08:44:50 Source:North American Vascular Biology Organization Author:Bernadette Englert Hits:0
Dear All,

Just to keep you up to date – the final program is now available online at
We are currently accepting Late-breaking abstracts through September 1 – see the web site for details. 
Genetics and Genomics of Vascular Disease Workshop
Late-breaking Abstract submission deadline: September 1
Genetics and Genomics of Vascular Disease Workshop
Sponsored by the North American Vascular Biology Organization
September 13-16, 2009
Cape Codder Resort and Spa
Hyannis, Cape Cod, Massachusetts, USA
Featuring a keynote address by Hal C. Dietz,
Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Organized by
Douglas Marchuk, Duke University and
Miikka Vikkula, de Duve Institute, Université catholique de Louvain
for program, registration, abstract submission and other information
Contact NAVBO – (301) 760-7745 or

The Workshop will bring together investigators employing The Workshop will bring together investigators employing genetic and genomic studies of traits related to the vasculature with more traditional vascular biologists in order to seed the cross-fertilization of both fields.   We hope to promote the use of genetic and genomic approaches to the study of vascular disease, and also promote the transfer of the wealth of knowledge of vascular biology to the genetic/genomic studies of vascular diseases.

Sunday, September 13th
Keynote Address – Marfan Disease and Related Disorders: From Molecules to Medicines
Hal C. Dietz, Howard Hughes Medical Institute, Johns Hopkins School of Medicine
Monday, September 14th
Vascular Disease in Metabolic Syndrome
Integrative genomic approaches to cardiovascular disease
          Timothy J. Aitman, Imperial College, London
RAGE: Inflammatory signaling in atherosclerosis and diabetes 
          Ann Marie Schmidt, Columbia University
Metabolomic profiling in metabolic disorders and cardiovascular disease
           Svati Shah, Duke University
Pathogenesis of Arteriovenous Malformation

Notch signaling in arterial venous hierarchy and arteriovenous malformation
          Rong A. Wang, University of California, San Francisco
Hereditary hemorrhagic telangiectasia and arteriovenous malformation
          S. Paul Oh, University of Florida, Gainesville
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease
      Patrick A. Murphy, University of California, San Francisco
Specific deletion of Jagged1 within endothelial and mesenchymal compartments clarifies its role in Alagille Syndrome
Ann Zovein, University of California, Los Angeles

Atherosclerosis and Coronary Artery Disease I
 GWAS for CAD:  Progress and promise
          Ruth McPherson, University of Ottawa, Canada
Systems genetics approach to cardiovascular disease
          Aldons J. Lusis, University of California, Los Angeles
A unique Multi-modality-omics approach provides a tool for the discovery of plaque-derived biomarkers
          Wouter J. Eijgelaar, Maastricht University
The Pix and integrin story: A link between focal adhesions and vascular stability
          Jing Liu, University of Calgary
Special Lecture

Poster Preview
  Presenters will give a one-minute summary of their posters
Endothelial microRNAs and postnatal angiogenesis
          William C. Sessa, Yale University
Poster Sessions and Exhibits

Tuesday September 15th
Genetic Determinants of Ischemic Disease
Genetic control of cerebral infarction
          Douglas A. Marchuk, Duke University
Genetic basis of collateral circulatory insufficiency
          James E. Faber, University of North Carolina, Chapel Hill
Quantification of collateral vessels in C57Bl/6 and Balb/c mice using ArterioJ
          Paul Johnston, University of California, San Francisco
Regulation of vascular endothelial cell function by the tumor suppressor NF1 
          Kevin Pumiglia, Albany Medical College
Genetic Determinants of Vascular Response
Genetic mechanisms of vascular remodeling induced by low blood flow
          Vyacheslav A. Korshunov, University of Rochester
Mapping the genetic determinants of microvasculature angiogenesis in mice
          Bruce Herron, Wadsworth Institute
The effect of genetic diversity on angiogenic responsiveness
          Michael S. Rogers, Children's Hospital Boston/Harvard Medical School
Thrombospondin-1, via CD47, blocks endothelial-dependent arterial relaxation by limiting endothelial nitric oxide synthase activation
          Jeff S. Isenberg, University of Pittsburgh
GWAS: Past, Present and Future
   David Delano, Illumina
Explore Cape Cod

Hemangioma pathogenesis
          Bjorn Olsen, Harvard Medical School
Vasculogenesis from hemangioma-derived multipotent stem cells
          Joyce Bischoff, Children's Hospital Boston
Forward and Reverse Genetic Studies of Vascular Disorders
Identification of intracranial aneurysm susceptibility loci using whole genome association
          Murat Günel, Yale University
Dissecting CADASIL pathophysiology using mouse models
          Anne Joutel, INSERM 
Wednesday September 16th
New Signaling Paradigms in Vascular Malformation
HEG-CCM signaling in vascular development and disease
          Mark L. Kahn, University of Pennsylvania
Pathogenesis of vascular malformations
          Miikka Vikkula, de Duve Institute, Université catholique de Louvain
Cerebral cavernous malformation protein 1 regulates vascular lumen by inducing endothelial polarity
          Maria Grazia Lampugnani, IFOM
CCM3 signaling through sterile 20-like kinases plays an essential role during cardiovascular development and in human cerebral cavernous malformations
          Xiangjian Zheng, University of Pennsylvania
Regulation of beta-catenin signaling by CCM1/KRIT1 and Rap1
          Angela J. Glading, University of Rochester 
Atherosclerosis and Coronary Artery Disease II
Whole-genome expression profiling of multiple organs in coronary artery disease: A systems approach
          Johan Björkegren, Karolinska Institute, Stockholm
Genomics of atherosclerosis: target validation in mouse models
          Esther Lutgens, University of Maastrichts
SNP mapping of the HHT3 interval on chromosome 5
          Claire L. Shovlin, Imperial College London
Concluding Remarks
          Douglas A. Marchuk and Miika Vikkula 

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